The liver is one of the largest organs in the body; about 3.5% of the body mass. It is situated just behind the diaphragm that separates the chest from the abdomen. The liver is very important and has many functions. Because of its central metabolic role it is affected by many disease processes that occur outside the liver such as endocrine (glandular) conditions. Liver disease in dogs can occur, but fortunately it can often be effectively managed.