Brain Tumor Clinical Study for Dogs with Glioma

Toca 511 & Toca FC Gene Transfer with Surgical Resection & Radiation Therapy
pup pictToca 511 is a nonlytic retroviral replicating vector that delivers a Cytosine Deaminase (CD) gene selectively to cancer cells. Toca FC is an extended-release tablet containing the antifungal drug, 5-FC (flucytosine). Toca FC is used in combination with Toca 511 because CD catalyzes the conversion of 5-FC, to the anti-cancer drug, 5-FU (5-fluorouracil).
Toca 511 is administered transcranially directly into the tumor following stereotactic biopsy. 3-6 weeks following Toca 511, surgical resection will be performed with the option for adjuvant radiation therapy.

The Toca 511 & Toca FC investigational study has been approved by:

  • VMTH Clinical Trial Review Board
  • UC Davis Institutional Animal Use and Care Committee
  • FDA

How It Works

We will be happy to review imaging data, diagnostics or clinical history for potential cases.
Dogs enrolled in the study will have the following procedures financially covered in addition to
Toca 511 ($12,000-15,000)

  • CT guided biopsy to confirm the diagnosis
  • Surgical resection of the tumor
  • Radiation therapy (stereotactic or standard)

All treatment decisions will be made in consultation with the owner and referring veterinarian.
Funded by The American Brain Tumor AssociationToca 511 Trial Anouncement

CT Brain biopsy and infusion

Glioma surgical resection

Radiation Therapy Planning


For information on enrollment, or to refer a patient:
Neurology/Neurosurgery Service
Christy Chessman (Service coordinator)
530 754 0606
[email protected]
VMTH Hospital Reception
530 752 1393
Peter J. Dickinson, BVSc, PhD, DACVIM (Neurology)
UC Davis
School of Veterinary Medicine
(530) 752-3412
For more information about
Toca 511 and Toca FC
please visit:
Article Source & Images

Oregon Veterinary Specialty Hospital (OVSH) has been serving the Portland and Beaverton area community since 1979. Drs. Steven F. Skinner (Neurology, Neurosurgery) and Robert T. Franklin (Internal medicine.) We welcome referrals from veterinarians all over the Pacific Northwest. Our goal is to help your pet regain health and live a long and happy life.

Oregon Veterinary Specialty Hospital

9339 SW Beaverton Hillsdale Hwy,
Beaverton, OR 97005.
Phone: 503.292.3001
Fax: 503.292.6808
Email: [email protected]